Wednesday, February 23, 2005A compound in the common daisy-like plant feverfew kills human leukemia stem cells and could form the basis for newer, more effective drugs for the disease.

American researchers at the University of Rochester Medical Center in New York say that it could take months to develop a useable drug from the compound, parthenolide.

However, they are working to do so with chemists at the University of Kentucky who have identified a water-soluble molecule with the same properties. The US National Cancer Institute has also accepted the work into its rapid access program, which aims to speed experimental drugs into human clinical trials.

“This research is a very important step in setting the stage for future development of a new therapy for leukemia,” says Rochester researcher Craig Jordan. “We have proof that we can kill leukemia stem cells with this type of agent, and that is good news.”

Parthenolide appears to target the roots of myeloid leukemia, stem cells, while current treatments including the relatively new drug Gleevec don’t. So, “You’re pulling the weed without getting to the root,” says Jordan.

Used for centuries to fight fevers, inflammation and arthritis, feverfew earned interest from the Rochester researchers after other scientists showed that it could prevent skin cancer in animal models.

So the researchers investigated how a concentrated form of the plant component parthenolide would affect leukemia cells and normal cells.

Comparing the impact of parthenolide to the common chemotherapy drug cytarabine, they found that parthenolide selectively killed leukemia cells while sparing normal cells better.

While the findings suggest that parthenolide is a good starting point for new drugs, people with leukemia aren’t being encouraged to take high doses of feverfew as they could not take enough of the remedy to halt the disease.

The research is reported in the journal Blood.

Thursday, February 22, 2007

Denial. Anger. Bargaining. Depression. Acceptance.

Originally formulated in 1973 by Elisabeth Kübler-Ross, these five stages are well-known to many as the “Five Stages of Grief“. However, despite their familiarity, the five-stage theory had remained untested empirically, until Paul K. Maciejewski, Ph.D., assistant professor of psychiatry at the Yale University School of Medicine and the Yale Bereavement Study completed several years of research, findings for which were published in the February 21 issue of the Journal of the American Medical Association (JAMA).

According to Dr. Kübler-Ross’s theory, denial is the first and most defining indicator of grief. The Yale Bereavement Study’s findings, in contrast, show acceptance to be the most common indicator, and yearning the strongest negative indicator.

The authors explain, “Disbelief decreased from an initial high at one month postloss, yearning peaked at four months postloss, anger peaked at five months postloss, and depression peaked at six months postloss. Acceptance increased steadily through the study observation period ending at 24 months postloss.”

Study author Holly Prigerson, associate professor of psychiatry at Harvard Medical School and director of the Dana-Farber Cancer Institute‘s Center for Psycho-Oncology and Palliative Care Research, says, “This would suggest that people who have extreme levels of depression, anger or yearning beyond six months would be those who might benefit from a better mental health evaluation and possible referral for treatment.”

The Yale Bereavement Study followed the progress of 233 participants from January 2000 through January 2003 who had lost family, most often a spouse, and was funded by the National Institute of Mental Health, the National Cancer Institute, the National Institute of Neurological Disorders and Stroke, the Center for Psycho-Oncology and Palliative Care Research, Dana-Farber Cancer Institute, and Women’s Health Research at Yale University.

Wednesday, January 18, 2012

Today, the English version of Wikipedia is taking part in a 24-hour ‘blackout’ to protest two proposed U.S. anti-piracy laws, the Stop Online Piracy Act and the PROTECT IP Act. The protest mirrors similar actions from other websites including Reddit and Boing Boing. The White House stated on Saturday that they “will not support legislation that reduces freedom of expression, increases cybersecurity risk, or undermines the dynamic, innovative global internet”.

In the midst of the Wikipedia blackout, executive director of the Wikimedia Foundation Sue Gardner answered some questions posed by Wikinews’ Tom Morris about the effectiveness of, and background to, the blackout.

((Tom Morris)) Do you think the blackout is going to actually be effective?

((Sue Gardner)) Yes. In my opinion, the blackout has two main goals—to raise awareness about the dangers of SOPA and PIPA, and to encourage readers to contact their elected representatives and give their views. The first has already been accomplished: there are already more than 4,000 stories in Google News about the blackout, and it was a trending topic on Twitter almost immediately. So we know we’ve been effective in raising awareness. What remains to be seen how many people will contact their elected officials.

((TM)) What do you say to people who have decided to leave the editing community as a result of the blackout?

((Gardner)) I hope nobody stops editing Wikipedia because of the blackout. I watched the community decision-making process unfold on the English Wikipedia, and I thought it was a good one. People first started talking about SOPA more than a month ago. Jimmy started the straw poll in mid-December. Over 1,800 English Wikipedians from many different countries participated in the discussion over the last three days. As the admins who closed it noted, this is by far the largest-ever number of participants in a community discussion on English Wikipedia, and the overwhelming majority of them supported action. So I would hope that anybody who opposes the blackout would also agree that the decision-making process was a good one, and would therefore be okay to accept it, however reluctantly.

((TM)) How much technical planning went into the blackout before the community consensus was decided on Monday night?

((Gardner)) Last Thursday Geoff Brigham [Ed: Wikimedia’s legal counsel] asked engineering to do an internal assessment of the technical implementation requirements, because the community discussions at that point were suggesting there would likely be some kind of action. Engineering did an initial assessment based on e.g. the Italian blackout, implications for search engines, etc., and then a lot of work happened over the weekend. The bulk of initial development and testing happened on a sprint on Martin Luther King Day, a public holiday in the United States, and the final launch development and testing sprint happened on Tuesday.

((TM)) Does the fact that this is affecting only English Wikipedia and not the sister projects and other language projects concern the Foundation?

((Gardner)) No. My understanding is that the English Wikipedia is the only project and language-version enacting a blackout, but that several other projects and language versions are putting up supportive banners, with the Italian Wkipedians doing a clickthrough informational interstitial. The German Wikipedia decided to put up banners even before consensus was reached on the English Wikipedia, and the Arabic Wikipedia, Italian Wikipedia and Commons later made the same decision. (There may be others, that I don’t know about.) I think that’s fine: each project and each language has different circumstances that argue for different types of action, or for no action. There is no one right answer that fits everybody.

((TM)) Some have said that the lack of participation by opponents of SOPA in the commercial sector (sites of the size of Twitter, Facebook, Google etc.) is going to hamper the effectiveness of the blackout – is this a concern?

((Gardner)) No. I don’t think anybody ever expected the big commercial sites to black out: most aren’t in a position to participate in something like this even if they wanted to. For example, they might have shareholders to answer to, participation might cost them significant revenue, or it could break contractual agreements (such as a commitment to maintain a certain level of uptime, or some other service delivery). Most sites are constrained by various commercial considerations: that makes Wikipedia’s participation particularly powerful and important.

((TM)) Given both the Italian shutdown and the SOPA blackout, is the Foundation going to come up with a policy or set of conditions which limit when these kind of things happen? There are plenty in the community who support the SOPA actions but are concerned that this will set a bad precedent.

((Gardner)) Yeah, I empathize with those people and to a certain extent I share that concern. The Wikimedia movement does not have a lot of experience with advocacy, and probably mistakes will get made. At this time the Wikimedia Foundation doesn’t have any plans to develop policy governing protests or advocacy work. But, I think it probably does make sense for the Foundation to create venues for these discussions so people can share thinking and expertise. So for example, we may create a mailing list dedicated to advocacy/lobbying. And there is some good thinking starting to happen [on the project-wide protests page on Meta].

Tuesday, June 16, 2009

An Oklahoma police officer is on paid administrative leave, following an altercation with ambulance personnel while they were transporting a patient to the hospital. Trooper Daniel Martin, a member of the Oklahoma Highway Patrol (OHP), was caught on video by his police vehicle’s dashboard-camera in a physical struggle with paramedic Maurice White, Jr. after Martin pulled the ambulance over. Martin had previously passed the ambulance while en route to another call, but came back and pulled over the ambulance. The incident occurred on May 24, and footage from the police dash-cam was released following a tort claim filed by paramedic White.

It has also been suggested that the previous call had in-fact been to pick up his wife from a police station who was then present in the car during the incident between Martin and the ambulance.

Footage by the OHP released Friday shows the ambulance personnel repeatedly informing Trooper Martin that they have a patient in the back of the ambulance that they are in the midst of transporting to the hospital. Martin yells at the ambulance driver for making what he claims was an obscene gesture – the ambulance driver asserts he raised both hands signalling confusion at the police officer’s actions. Trooper Martin can be heard telling the ambulance driver “I’m going to give you a ticket for failure to yield, and when I go by you saying ‘What’s going on?’ you don’t need to give me no hand gestures now, I ain’t going to put up with that [expletive], do you understand me?”

The video from the police dash-cam is eight minutes long, and paramedic White can be seen twice being pushed up against his ambulance by Trooper Martin. In one instance, Martin shoves White up against the ambulance while gripping his neck tightly with his other hand. In a written statement, paramedic White described the hold placed on him by the Trooper, stating “he engaged my trachea in a claw-like grip digging his nail into my neck while partially shutting off my air supply.”

The sister of the patient in the ambulance, Clara Harper, was following the ambulance and witnessed the incident. Harper later viewed the footage from the police dash-cam, and she stated to Tulsa World paramedic White “never once became aggressive to that trooper.” She asserted that “He did nothing wrong.” After the ambulance was allowed to continue transporting the patient to the hospital, Harper got into the ambulance to be with her sister. “She was scared, and I was trying to calm her down and telling her everything was going to be all right,” said Harper.

Paramedic White was interviewed by KOKI-TV, and recounted his thoughts as the incident was taking place. He stated his main concern was for his ambulance patient: “It was surrealistic because I’ve never had such an experience. My biggest concern was for the patient. If there’s any nightmare from this, it’s because of what that mother, that patient, had to go through.” White’s attorney told KOKI-TV that if White deemed the arrest to be unlawful, he had the right to resist it. White is a paramedic for Creek Nation Emergency Medical Services in Oklahoma. He told FOX News he was surprised at the actions of the police trooper. “He’s taken an oath, just as I have, to protect and serve. I could not believe that this was happening,” said White.

The Oklahoma Department of Public Safety decided to release the police dash-cam video publicly after amateur video of the incident was posted to the video-sharing website YouTube. Captain Chris West, spokesman for the OHP, explained why the video was not released earlier. “We’ve been well aware of the fact that this incident has drawn enormous attention, but made the decision to protect the integrity of the investigation, any and all relevant evidence, as well as the rights of the department employees,” said West. Prior to the release of the dash-cam video, a relative of the patient had posted video of the incident to YouTube. The son of the ambulance patient can be seen in a video stating to the camera “Highway patrolman pulled over my mom’s ambulance because he’s mad we didn’t pull over, and he tried to arrest … the EMT from taking my mother to the hospital.”

Richard O’Carroll, the lawyer for paramedic White, said that Trooper Martin abused his authority as a police officer. “Everything on this needs to relate back to why are we here? One man is there protecting a patient and one man is there abusing his authority and throwing his weight around,” said O’Carroll. White’s attorney filed a tort claim on behalf of his client in order to get the video of the police vehicle’s dash-cam released. Trooper Martin’s lawyer says he did not realize a patient was in the ambulance at the time of the incident.

O’Carroll explained the decision of paramedic White not to use sirens while transporting his patient to the hospital: “There was a reason he wasn’t running sirens. There was a suggestion of chest pains and a heart condition and sirens aggravate these conditions by increasing the blood pressure.” However the attorney for Trooper Martin, Gary James, said that the ambulance was not exempt from regulations because it did not have its sirens on. “If they’re not running their sirens or lights, they don’t get afforded any emergency vehicle exemptions,” said James. The OHP chief is handling an internal review into the incident. As of June 1, Trooper Martin has been on paid administrative leave.

Friday, September 9, 2005

New Orleans, Louisiana —After Category 4 storm Hurricane Katrina slammed into New Orleans, on the night before August 29, 2005, several flood control constructions failed. Much of the city flooded through the openings. One of these was the flood wall forming one side of the 17th Street Canal, near Lake Pontchartrain. The U.S. Army Corps of Engineers (USACE) is the primary agency for engineering support during such emergencies. A USACE team was assessing the situation in New Orleans on the 29th, water flow was stopped September 2nd, and the breach was closed on September 5th.

Sunday, May 27, 2007

The Royal Canadian Mounted Police (RCMP), the United States Border Patrol and local officials from both sides are looking into tightening security at a Quebec library. The library has been deliberately on the border of Canada and the U.S. since it was built in 1904 by American sawmill owner Carlos Haskell and Canadian wife Martha Stewart Haskell for availability to both countries.

At Haskell Free Library and Opera House, in Rock Island, Quebec, a black line diagonally runs across the center of the library to mark the international border. Ironically the line puts the seats in the U.S. and the opera stage in Canada.

Both towns share the same water supply, sewer systems and emergency crews thus they cross the border without going against the law. In total, there are three streets that cross the border and there are cameras on both sides to monitor illegal activity, but that doesn’t tighten border security enough officials say.

“There’s been an increase in illegal activity, both north and south, in the last little while,” said operations officer for the Border Patrol’s Swanton sector, Mark Henry.”There have been some significant cases. This all fits in to the larger picture of the Border Patrol strategy to gain operational control of our borders.”

“I don’t think they’re aiming at people who go pick up groceries and come back. It’s people that want to use this in a bad way,” says Cpl. Luc Bessette, a spokesman for the RCMP.

To enter the U.S. at Haskell Free Library and Opera House, in Rock Island, Quebec, all one needs is directions to go to Stanstead, Quebec, directions to the local library and walk through the doors; they have illegally entered Derby Line, Vermont, U.S. If one walks across from Stanstead St. to Derby Line they will be at the checkout in the U.S., go to the library from Derby Line to Stanstead St. and they have officially entered back into Canada. The international border also is on Canusa St., a residential street in Stanstead, Quebec and Beebe Plain, Vermont.

If someone wants to see their neighbour across the street, they would be re-entering the U.S. Anyone who comes from Stanstead St. to Derby Line, to visit their neighbour, must report to Customs or they could be sent to jail for illegally entering. However, residents do not need to notify Customs if they cross the border inside buildings.

Currently, the front door is in Vermont and if Quebecers couldn’t enter the front they would have to go through the back way. If Americans wanted to park in the parking lot they couldn’t because it is legally in Canada.

A meeting will take place this 19 June at 7 p.m. local time asking whether residents want to prevent people from crossing the border regularly or, in some cases, illegal crossings. During a meeting last Thursday in Stanstead, Quebec, local officials from both countries (towns) said border walls and fences will not be put up due to local residents’ concerns. They say there are other alternatives.

There is also a movement to separate Vermont from the U.S. or to make it the 11^th province of Canada, with three territories. The website “Vermont Canada” says the state should join Canada due to its remaining liberal policies as opposed to the U.S.