Tuesday, July 7, 2009

A permanent memorial for the victims of the July 7, 2005 London bombings has been unveiled in Hyde Park, London, England. Today is the fourth anniversary of the bombings, when 52 people were killed by suicide bombers on board three Underground trains and a bus.

52 stainless steel columns standing 3.5m (11.5ft) tall were inaugurated in the presence of Prince Charles, the Duchess of Cornwall Camilla Bowles, Prime Minister Gordon Brown, London Mayor Boris Johnson and Minister for London, Tessa Jowell.

Each column represented “a unique person and a unique grief” according to the Minister for London.

Jowell continued, “Each one casts a shadow just as they do – each one standing tall and proud just as they did, and each one will in an individual way absorb and reflect light just as they did.”

A 1.4 tonne stainless steel plaque with the names of the people killed was also unveiled.

Prince Charles laid a wreath on behalf of the nation. The Duchess of Cornwall left a floral tribute for the families of the victims.

The families themselves laid roses and then met the prince and the duchess.

Monday, March 21, 2005

Automobile industry pioneer, John DeLorean, died Saturday in a New Jersey hospital by complications from a stroke.

DeLorean was born in 1925 in Detroit, Michigan to European immigrant parents. He received an education in automotive engineering and quickly rose through the ranks of Packard and later General Motors (GM). DeLorean was credited with the development of the Pontiac GTO, which helped introduce the era of “muscle cars”. By 1965, DeLorean led the entire Pontiac division, and four years later was promoted to the prestigious position of leading GM’s Chevrolet.

In 1973, DeLorean quit General Motors and started his own company, the De Lorean Motor Company. The company’s product was the DMC-12, an unusual car featuring an unpainted, stainless-steel exterior and gull-wing doors. The company started production in 1981 but failed less than two years later, having produced under 9,000 vehicles. Despite the company’s failure and the car’s dismal sales, the car itself gained a cult following after the release of the 1985 movie Back to the Future which featured the car as a time-travel machine.

DeLorean himself was in nearly as much trouble as his company. In 1982 he was arrested for attempting to sell $24 million worth of cocaine to undercover police, and after his company’s failure, he became involved in a multitude of lawsuits alleging investor fraud. Though DeLorean successfully resolved the cocaine case after claiming entrapment, his other legal cases would drag on until 1999, when he declared bankruptcy.

Friday, September 14, 2007

The Kennedy Center announced that its 30th presentation of the Kennedy Center Honors would go to pianist Leon Fleisher, comedian Steve Martin, singer Diana Ross, director Martin Scorsese and musician Brian Wilson. The Center was opened to the public in 1971 and was envisioned as part of the National Cultural Center Act, which mandated that the independent, privately-funded institution would present a wide variety of both classical and contemporary performances, commission the creation of new artistic works, and undertake a variety of educational missions to increase awareness of the arts.

In a statement, Kennedy Center Chairman Stephen A. Schwarzman said that “with their extraordinary talent, creativity and perseverance, the five 2007 honorees have transformed the way we, as Americans, see, hear and feel the performing arts.”

Fleisher, 79, a member of the Peabody Institute‘s music faculty, is a pianist who lost use of his right hand in 1965 due to a neurological condition. He became an accomplished musician and conductor through the use of his left hand. At 67, he regained the use of his right hand. With the advent of Botox therapy, he was once more able to undertake two-hand performances in 2004, his first in four decades. “I’m very gratified by the fact that it’s an apolitical honor,” Fleisher said. “It is given by colleagues and professional people who are aware of what [an artist] has done, so it really is apolitical — and that much more of an honor.”

Martin, 62, a comedian who has written books and essays in addition to his acting and stand-up comedy career, rose to fame during his work on the American television program Saturday Night Live in the 1970’s. Schwarzman praised his work as that of a “renaissance comic whose talents wipe out the boundaries between artistic disciplines.” Martin responded to the honor saying, “I am grateful to the Kennedy Center for finally alleviating in me years of covetousness and trophy envy.”

Ross, 63, was a product of Detroit‘s Brewster-Douglass Projects when as a teeager she and friends Mary Wilson and Florence Ballardis formed The Supremes, a ground-breaking Motown act. She portrayed singer Billie Holiday in the 1972 film Lady Sings the Blues, which earned her an Oscar nomination and a Golden Globe award. “Diana Ross’ singular, instantly recognizable voice has spread romance and joy throughout the world,” said Schwarzman. Ross said she was “taken aback. It is a huge, huge honor and I am excited to be in this class of people.”

Scorsese, 64, is one of the most accomplished directors the United States ever produced, whose work includes Mean Streets, Taxi Driver, GoodFellas, Cape Fear, The Last Temptation of Christ and The Departed, for which he won a 2006 Academy Award for Best Director after being nominated eight times. Scorsese said, “I’m very honored to be receiving this recognition from the Kennedy Center and proud to be joining the company of the very distinguished individuals who have received this honor in years past.”

Wilson, 65, along with his brothers Dennis and Carl, formed the Beach Boys in 1961. They had a series of hits that included “Surfin’ U.S.A.” and “Wouldn’t It Be Nice.” Their 1966 album Pet Sounds is considered one of the most influential recordings in American music. “This is something so unexpected and I feel extremely fortunate to be in the company of such great artists,” said Wilson, who is currently on tour.

The Kennedy Center’s board of trustees is responsible for selecting honorees for “lifetime contributions to American culture through the performing arts.” Previous honorees, including Elton John and Steven Spielberg, also submitted recommendations. A wide variety of people were under consideration, including Emanuel Ax, Evgeny Kissin, Renee Fleming, Laurence Fishburne, Francis Ford Coppola, Melissa Etheridge and Kenny Chesney.

President Bush and first lady Laura Bush will attend the center’s presentation at its opera house on December 2, 2007, which will broadcast on December 26 on CBS.

Friday, September 1, 2006

Results of gene therapy trials at the US National Cancer Institute, Bethesda to fight cancer published online yesterday by the scientific journal Science show some levels of success. However experts have warned that despite the promise more work is needed for this to become a viable cure.

Dr Stephen Rosenberg, who lead the research team, said “It’s important to emphasize this is a highly experimental treatment that’s still in the course of development.”

The team treated 17 terminal skin cancer patients with modified cells from their immune systems. The technique uses genetically modified white blood cells (more specifically T cells) to attack and kill the cancer cells. Of the 17 subjects only 2 were cured of the disease (an aggressive form of skin cancer called a melanoma which is usually fatal in advanced stages). Before the treatment, which lasted 18 months, the patients were only expected to live for up to 6 months. The remaining 15 patients were not affected by the treatment.

One of the successful patients was Mark Origer (53) from Wisconsin. He has been fighting cancer since first being diagnosed in 1999. After finding out about the new trial on the internet he applied and, after interviews, was accepted along with 16 other candidates. The treatment removed Origer’s melanoma and also shrunk another tumor in his liver – to the extent it could be removed surgically. Doctors confirmed he was free of the disease last week, nearly 2 years after treatment began. A second man (39) was cleared of his cancer which had spread to the lungs, liver and lymph nodes. Cancer that progresses to the lymph nodes is usually untreatable and fatal.

T cells can attack and destroy bacteria and other harmful cells like cancer cells. However cancer cells sometimes reduce the signals on their outer surface by which they are recognised, so the immune system cannot affect them. Gene therapy involves modifying some of a patients T cells to contain a new receptor. (Receptors are what enable the immune cell to identify harmful cells, like those corrupted by viruses. The new receptor is inserted with the use of a viral vector, i.e. a virus made safe to insert the receptor in the cell.

In the trial, T Cells were removed from each patient and modified in the laboratory. Patients underwent chemotherapy to kill most of their current immune system, which was replaced by the mutated cells. The modified cells successfully survived after injection into the body – making up 10% of the subject’s T cell count during the first 2 months. The team is now looking for ways to enable the cells to survive longer and in greater numbers.

Experts have called this a significant technical advance but warn that more patients need testing and the technique refining before any conclusive results can be drawn. Dr Edel O’Toole, consultant dermatologist and British Skin Foundation spokesman, said: “I think that the success of this approach in two patients shows promise, however 15 patients did not respond to the treatment suggesting that further work is needed to optimise this approach for all patients, which could take many years.”

Rosenberg now hopes to run a new trial with possibly stronger gene therapy treatments, he is currently awaiting FDA approval.

Gene therapy was much hyped after it’s first successful application in so called “bubble boys” (patients with severe combined immunodeficiency). After follow-up, these trials were stopped when it was discovered that three of eleven patients in one trial had developed leukemia.